THE NATURE OF BENCE-JONES PROTEINS

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The Nature of Bence-jones Proteins

The chemical relations among Bence-Jones proteins, myeloma proteins, and normal gamma-globulins have been investigated by a variety of means. Starch gel electrophoresis in 8 M urea of reduced alkylated Bence-Jones proteins yielded patterns of bands corresponding to those of the light (L) polypeptide chains of the dissociated myeloma protein from the same patient. One instance in which this corr...

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Metabolism of Bence Jones Proteins.

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Some Observations on the Nature of the ;Bence-Jones' Protein.

The peculiar protein found in the urine in cases of multiple myeloma has, since the time when Bence-Jones first described it,' been found on but few occasions, owing to the rarity of the disease with which it is associated. Notwithstanding this, a great deal of work has been done towards elucidating its characters. The result has been that the various workers have placed it in different classes...

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Human Antibody Reacting with Bence Jones Proteins

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The optical rotatory dispersion of five individual specimens of Bence-Jones proteins was investigated, including the far ultraviolet spectral zone. The Mo5tt constants (bo) were determined, and either low positive or low negative values were found. The rotatory dispersion curves of all specimens had flat negative minima at 220 to 235 rnp and positive maxima at 204 to 212 rnp. Denaturation with ...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1962

ISSN: 1540-9538,0022-1007

DOI: 10.1084/jem.116.2.207